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Recombinant Human VNN2 Protein (His Tag)
SKU: PKSH033354-50
Recombinant Human VNN2 Protein (His Tag)
| SKU # | PKSH033354 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Glycosylphosphatidyl Inositol-Anchored Protein GPI-80, Protein FOAP-4, VNN2, Vanin-2, Vascular Non-Inflammatory Molecule 2 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln23-Ser492 |
| Accession | O95498 |
| Calculated Molecular Weight | 54.2 kDa |
| Observed Molecular Weight | 68 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 7.5. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Vascular Non-Inflammatory Molecule 2 (VNN2) is a member of the CN hydrolase family. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. they possess pantetheinase activity, which may play a role in oxidative-stress response. VNN2 is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. VNN2 involved in the thymus homing of bone marrow cells. In addition, VNN2 may regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.