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Recombinant Mouse Hepcidin/Hepc protein (TRX,His tag)
SKU: PDEM100034-100
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Recombinant Mouse Hepcidin/Hepc protein (TRX,His tag)
| SKU # | PDEM100034 |
| Expression Host | E. coli |
Description
| Synonyms | Hepcidin;HEPC_MOUSE;Hamp;Hamp1;Hepc;Hepc1 |
| Species | Mouse |
| Expression_host | E.coli |
| Sequence | Asp59-Thr83 |
| Accession | Q9EQ21 |
| Mol_Mass | 22.6 kDa |
| AP_Mol_Mass | 25 kDa |
| Tag | N-Trx-His |
| Bio_Activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.