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Recombinant Mouse HP1α protein (His tag)
SKU: PDEM100072-100
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Recombinant Mouse HP1α protein (His tag)
| SKU # | PDEM100072 |
| Expression Host | E. coli |
Description
| Synonyms | HP1 alpha;Antigen p25;CBX5;Chromobox 5;Epididymis luminal protein 25;HEL25;Heterochromatin protein 1;HP1A |
| Species | Mouse |
| Expression_host | E.coli |
| Sequence | Met 1-Ser 191 |
| Accession | Q61686 |
| Mol_Mass | 20.9 kDa |
| AP_Mol_Mass | 25 kDa |
| Tag | N-His |
| Bio_Activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.