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Recombinant Mouse IGFBP-7/IGFBP7 Protein (His Tag)– MSE Supplies LLC

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Recombinant Mouse IGFBP-7/IGFBP7 Protein (His Tag)

SKU: PKSM041324-50

  • $ 35495
  • Save $ 4259



Recombinant Mouse IGFBP-7/IGFBP7 Protein (His Tag)

 

SKU # PKSM041324
Expression Host HEK293 Cells

 

 

Description

Synonyms AGM, Fstl2, IBP-7, IGF-binding protein 7, IGFBP-rP1, IGFBP7, Igfbp7, Insulin-like growth factor-binding protein 7, MAC25 protein, Mac25, TAF, Tumor-derived adhesion factor
Species Mouse
Expression Host HEK293 Cells
Sequence Ser26-Leu281
Accession Q61581
Calculated Molecular Weight 27.2 kDa
Observed Molecular Weight 32-35 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, 150mM NaCl, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. Human and mouse IGFBP7 are highly homologous and share 94% aa sequence identity. It is expressed in many normal tissues and in cancer cells. It is abundantly expressed in high endothelial venules (HEVs) of blood vessels in the secondary lymphoid tissues. It binds IGF and insulin with very low affinity and has been shown to enhance the mitogenic actions of IGF and insulin. IGFBP7 also has IGF/insulin-independent activities. It interacts with heparan sulfate proteoglycans, type IV collagen, and specific chemokines. It supports weak cell adhesion, promotes cell spreading on type IV collagen, and stimulates the production of the potent vasodilator PGI2. It modulates tumor cell growth and has also been implicated in angiogenesis.