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Recombinant Mouse IMPAD1/IMP3 Protein (His Tag)
SKU: PKSM041326-50
Recombinant Mouse IMPAD1/IMP3 Protein (His Tag)
| SKU # | PKSM041326 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | IMPA3 , Impad1, Inositol monophosphatase 3 |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Glu51-His356 |
| Accession | Q80V26 |
| Calculated Molecular Weight | 34.3 kDa |
| Observed Molecular Weight | 38 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 7.5. |
| Reconstitution | Not Applicable |
Background
IMPAD1 protein (IMPA3, gPAPP or IMPase 3) belongs to the inositol monophosphatase family. It is found in Purkinje cells, brain stem, lung and chondrocytes. Mouse IMPAD1 gene encodes a type II transmembrane Golgi-embedded glycoprotein with 356 amino acid residues which generates a 306 amino acid residues mature protein after processing. It is expressed in embryo, and in theory may catalyze myo-inositol monophosphate to myo-inositol. Free myo-inositol is used to generate inositol phospholipid, an essential component of intracellular signaling pathways that mobilize calcium. Mouse IMPAD1 exhibits 91% sequence identity with the human homologue.