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Recombinant Mouse Uteroglobin/SCGB1A1 Protein (His tag)
SKU: PDMM100033-100
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Recombinant Mouse Uteroglobin/SCGB1A1 Protein (His tag)
| SKU # | PDMM100033 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CC10, CC16, CCPBP, CCSP, Cc10, Clara cell 17 kDa protein, Clara cell phospholipid-binding protein, Clara cells 10 kDa secretory protein, PCB-BP, PCB-binding protein, Scgb1a1, Secretoglobin family 1A member 1, UG, UGB, Ugb, Uteroglobin, Utg |
| Species | Mouse |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Phe 96 |
| Accession | Q06318 |
| Calculated Molecular Weight | 10.5 kDa |
| Observed Molecular Weight | 10 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
Background
Uteroglobin(UG, SCGB1A1) is the founding member of the secretoglobin family of small,secreted, disulfide-bridged dimeric proteins found only in mammals. This protein is mainly expressed in lung, with anti-inflammatory/immunomodulatory properties. CCAAT/enhancer-binding proteins(C/EBPs) are the major transcription factors for the regulation of SCGB1A1 gene expression, whereas FOXA1 had a minimum effect on the transcription. Uteroglobin is a multifunctional protein with anti-inflammatory/immunomodulatory properties. Uteroglobin inhibits soluble phospholipase A(2) activity and binds and perhaps sequesters hydrophobic ligands such as progesterone, retinols, polychlorinated biphenyls, phospholipids, and prostaglandins. In addition to its anti-inflammatory activities, Uteroglobin manifests antichemotactic, antiallergic, antitumorigenic, and embryonic growth-stimulatory activities. Uteroglobin is a potential drug target. The mechanism of Uteroglobin action is likely to be even more complex as it also functions via a putative receptor-mediated pathway.