Total Price: $0.00
Contact Information
Recombinant Rat Angiopoietin-1/ANG1 Protein (His tag)
SKU: PDER100042-100
To better serve you, we would like to discuss your specific requirement.
Please Contact Us for a quote.
Recombinant Rat Angiopoietin-1/ANG1 Protein (His tag)
| SKU # | PDER100042 |
| Expression Host | E. coli |
Description
| Synonyms | AGP1, AGPT, ANG-1, ANGP1_RAT, ANGPT1, Ang1, Angiopoietin-1, angiopoietin 1 |
| Species | Rat |
| Expression Host | E.coli |
| Sequence | Asn304-Ala450 |
| Accession | O35460 |
| Calculated Molecular Weight | 16.1 kDa |
| Observed Molecular Weight | 18 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Angiopoietin-1 (Ang-1) is a secreted glycoprotein that plays a critical role in the development and maintenance of the vascular system. The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. Angiopoietin-1 can protect against pulmonary arterial hypertension, reduce the extent of fibrosis and remodeling in infarcted diabetic myocardium, and enhance tumor progression and metastasis.