Total Price: $0.00
Contact Information
Recombinant Rat FGG/Fibrinogen Gamma Chain Protein (His tag)
SKU: PDER100078-100
To better serve you, we would like to discuss your specific requirement.
Please Contact Us for a quote.
Recombinant Rat FGG/Fibrinogen Gamma Chain Protein (His tag)
| SKU # | PDER100078 |
| Expression Host | E. coli |
Description
| Synonyms | FIBG, Fibrinogen gamma chain, fibrinogen gamma-b chain |
| Species | Rat |
| Expression Host | E.coli |
| Sequence | Gln 26-Pro 445 |
| Accession | P02680 |
| Calculated Molecular Weight | 46.1 kDa |
| Observed Molecular Weight | 60 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.