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Recombinant Rat Interleukin-12 Subunit Beta/IL-12B Protein (His tag)
SKU: PDMR100029-100
Recombinant Rat Interleukin-12 Subunit Beta/IL-12B Protein (His tag)
| SKU # | PDMR100029 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | NKSF, IL-12/IL-23 p, IL-12 subunit p, NK cell stimulatory factor chain, NK cell Stimulating Factor Chain, CLMF, CLMF p, IL12 p, CLMF2, Cytotoxic lymphocyte maturation factor 40 kDa subunit, Cytotoxic Lymphocyte Maturation Factor 40 kDa subunit (CLMF p40), IL12, IL-12 p40, IL12 p70, IL-12 p70, IL-12/IL-23 p40, NK cell Stimulating Factor Chain 2, p40, IL-12B, NKSF2, Interleukin-12 subunit beta, CLMF p40, IL-12 subunit p40, NK cell stimulatory factor chain 2, IL 12B, Il12b |
| Species | Rat |
| Expression Host | HEK293 Cells |
| Sequence | Met1-Ser335 |
| Accession | E9PU71 |
| Calculated Molecular Weight | 36.8 kDa |
| Observed Molecular Weight | 42 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
Background
Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.