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Recombinant SARS-CoV-2 NSP3 Protein
SKU: PKSV030325-50
Recombinant SARS-CoV-2 NSP3 Protein
| SKU # | PKSV030325 |
| Expression Host | E.coli |
Description
| Synonyms | nsp3;PL-PRO;Papain-like proteinase;X domain(Macro domain) |
| Species | SARS-CoV-2 |
| Expression_host | E.coli |
| Sequence | Glu1024-Gln1198 |
| Accession | QHD43415.1 |
| Mol_Mass | 22.0 kDa |
| Tag | N-His |
| Bio_Activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyopilized from PBS pH7. 4,0.02%NLS, 1mM EDTA, 4%trehalose,1% mannitol. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Targeting PLpro with antiviral drugs may have an advantage in not only inhibiting viral replication but also inhibiting the dysregulation of signaling cascades in infected cells that may lead to cell death in surrounding, uninfected cells.