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Recombinant Human 15-PGDH Protein (His Tag)(Active)– MSE Supplies LLC

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Recombinant Human 15-PGDH Protein (His Tag)(Active)

SKU: PKSH031209-50

  • £63200
  • Save £7100



Recombinant Human 15-PGDH Protein (His Tag)(Active)

 

SKU # PKSH031209
Expression Host E.coli

 

 

Description

Synonyms 15-Hydroxyprostaglandin Dehydrogenase [NAD(+)], 15-PGDH, HPGD, PGDH, PGDH1, PHOAR1, Prostaglandin Dehydrogenase 1, SDR36C1
Species Human
Expression Host E.coli
Sequence Met 1-Gln 266
Accession NP_000851.2
Calculated Molecular Weight 29.7 kDa
Observed Molecular Weight 27 kDa
Tag C-His
Bio-activity Measured by the production of NADH during the oxidation of PGF2α. The specific activity is > 1, 500 pmoles/min/μg.
  

 

Properties

Purity > 92 % as determined by reducing SDS-PAGE.
Endotoxin Please contact us for more information.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM DTT, 10% glycerol, pH 7.5
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.


Background

15-hydroxyprostaglandin dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and PGDH1, is a member of the short-chain dehydrogenases/reductases (SDR) family. Prostaglandins (PGs) play a key role in the onset of labor inmany species and regulate uterine contractility and cervicaldilatation. Therefore, the regulation of prostaglandin outputby PG synthesizing and metabolizing enzymes in the human myometrium may determine uterine activitypatterns in human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. HPGD is down-regulated by cortisol, dexamethasone and betamethasone and down-regulated in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the regulation of events that are under the control of prostaglandin levels. HPGD catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells. Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal recessive (PHOAR), cranioosteoarthropathy (COA),and isolated congenital nail clubbing.