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Recombinant Human AGT Protein (His tag)
SKU: PDMH100052-100
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Recombinant Human AGT Protein (His tag)
| SKU # | PDMH100052 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ANGT, ANHU, ANRT, AT-2, Aangiotensinogen, Alpha 1 antiproteinase antitrypsin, Ang, Angiotensin I, Angiotensin-3, PAT, SERPINA8, Serpin A8 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met1-Glu476 |
| Accession | P01019 |
| Calculated Molecular Weight | 52.3 kDa |
| Observed Molecular Weight | 60 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
Angiotensinogen is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Genetic variations in Angiotensinogen are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the encoding gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.