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Recombinant Human AMIGO2 Protein (aa 1-398, His Tag)
SKU: PKSH030569-50
Recombinant Human AMIGO2 Protein (aa 1-398, His Tag)
| SKU # | PKSH030569 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ALI1, AMIGO-2, Alivin-1, Amphoterin-Induced Protein 2, DEGA, Differentially Expressed in Gastric Adenocarcinomas |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Thr398 |
| Accession | NP_862830.1 |
| Calculated Molecular Weight | 42.3 kDa |
| Observed Molecular Weight | 58-63 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
AMIGO2 contains Ig-like C2-type (immunoglobulin-like) domain, 6 LRR (leucine-rich) repeats, 1 LRRCT domain and 1 LRRNT domain. It belongs to the immunoglobulin superfamily, AMIGO family. AMIGO2 may mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. It is required for depolarization-dependent survival of cultured cerebellar granule neurons. AMIGO2 may also contribute to signal transduction through its intracellular domain. It may play a role in the tumorigenesis of a subset of gastric adenocarcinomas. AMIGO2 is highly expressed in breast, ovary, cervix, and uterus.