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Recombinant Human Angiopoietin-1/ANG1 (N-Fc)
SKU: PKSH033955-50
Recombinant Human Angiopoietin-1/ANG1 (N-Fc)
| SKU # | PKSH033955 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | AGP1, AGPT, ANG-1, ANGPT1, Ang1, Angiopoietin-1, angiopoietin 1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Asp256-Phe498 |
| Accession | Q15389 |
| Calculated Molecular Weight | 53.9 kDa |
| Observed Molecular Weight | 55-65 kDa |
| Tag | N-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Angiopoietin-1 (Ang-1) is a secreted glycoprotein that plays a critical role in the development and maintenance of the vascular system. The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. Angiopoietin-1 can protect against pulmonary arterial hypertension, reduce the extent of fibrosis and remodeling in infarcted diabetic myocardium, and enhance tumor progression and metastasis.