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Recombinant Human Apolipoprotein H/ApoH Protein (His Tag)
SKU: PKSH032087-50
Recombinant Human Apolipoprotein H/ApoH Protein (His Tag)
| SKU # | PKSH032087 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | APC inhibitor, APOH, Activated Protein C-Binding Protein, Anticardiolipin Cofactor, Apo-H, Apolipoprotein H, B2G1, B2GP1, B2GPIBeta(2)GPI, BG, Beta-2-Glycoprotein 1, Beta-2-Glycoprotein I |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gly20-Ser345 |
| Accession | P02749 |
| Calculated Molecular Weight | 37.3 kDa |
| Observed Molecular Weight | 45-70 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Apolipoprotein H (ApoH) is a 50 kDa variably glycosylated member of the complement control superfamily of proteins. Human ApoH is a major phospholipid binding protein and an important component to measure in the assessment of anti-phospholipid syndrome. Hepatocyte-derived ApoH binds to negatively charged phospholipids . It circulates as a component of lipoprotein particles and as a lipid-free serum protein. Human ApoH is also more specific than anti-cardiolipin antibodies and its presence correlates better with thrombotic risk. Mature human ApoH shares 76% and 82% aa sequence identity with mouse and rat ApoH.