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Recombinant Human ASB13 Protein (His Tag)
SKU: PKSH032070-50
Recombinant Human ASB13 Protein (His Tag)
| SKU # | PKSH032070 |
| Expression Host | E.coli |
Description
| Synonyms | ASB13, Ankyrin repeat and SOCS box protein 13 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Asn278 |
| Accession | Q8WXK3 |
| Calculated Molecular Weight | 31.4 kDa |
| Observed Molecular Weight | 28 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, 4M Urea, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Ankyrin repeat and SOCS box protein 13(ASB13) is a member of the ankyrin repeat and SOCS box-containing (ASB) family. ASB13 contain six ankyrin repeats sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. ASB13 may be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.