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Recombinant Human ATXN7L1 protein (His tag)
SKU: PDEH100313-100
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Recombinant Human ATXN7L1 protein (His tag)
| SKU # | PDEH100313 |
| Expression Host | E. coli |
Description
| Synonyms | Ataxin-7-like protein 1;ATXN7L1;Ataxin-7-like protein 1;Ataxin-7-like protein 4 |
| Species | Human |
| Expression_host | E.coli |
| Sequence | Met 1- Ala 146 |
| Accession | Q9ULK2-2 |
| Mol_Mass | 16.0 kDa |
| AP_Mol_Mass | 20 kDa |
| Tag | N-His & C-His |
| Bio_Activity | Not validated for activity |
Propertie
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin level | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis |
Background
ATXN7 is found in the cytoplasm of all the populations of neurons analyzed in control brains, but nuclear labeling is observed in some neurons with a frequency and intensity weakly correlated with the topography of lesions in patients. Ataxin-7 is a component of the Tata binding protein (TBP)-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA), which is implicated in several steps of transcriptional regulation such as histone acetylation/deubiquitinylation and recruitment of the preinitiation complex to promoters.