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Recombinant Human BAG2 Protein (His Tag)
SKU: PKSH032114-50
Recombinant Human BAG2 Protein (His Tag)
| SKU # | PKSH032114 |
| Expression Host | E.coli |
Description
| Synonyms | BAG Family Molecular Chaperone Regulator 2, BAG-2, BAG2, Bcl-2-Associated Athanogene 2 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Asn211 |
| Accession | O95816 |
| Calculated Molecular Weight | 25.9 kDa |
| Observed Molecular Weight | 25-30 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, 1mM DTT, 10% Glycerol, pH8.0. |
| Reconstitution | Not Applicable |
Background
BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is a important component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex. In mammalian cells BAG1, BAG2, and BAG3 bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.