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Recombinant Human BCL2L1/Bcl-XL Protein (His Tag)
SKU: PKSH033757-50
Recombinant Human BCL2L1/Bcl-XL Protein (His Tag)
| SKU # | PKSH033757 |
| Expression Host | E.coli |
Description
| Synonyms | Apoptosis Regulator Bcl-X, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-2-Like Protein 1, Bcl-X, Bcl2-L-1, PPP1R52, bcl-xL, bcl-xS |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met1-Arg212 |
| Accession | Q07817 |
| Calculated Molecular Weight | 24.9 kDa |
| Observed Molecular Weight | 29 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM HEPES, 50mM KCl, 20% Glycerol, pH 7.5. |
| Reconstitution | Not Applicable |
Background
Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.