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Recombinant Human BLK Protein (His Tag)
SKU: PKSH032011-50
Recombinant Human BLK Protein (His Tag)
| SKU # | PKSH032011 |
| Expression Host | E.coli |
Description
| Synonyms | B Lymphocyte Kinase, BLK, MODY11, Tyrosine-Protein Kinase Blk, p55-Blk |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Gly2-Pro505 |
| Accession | P51451 |
| Calculated Molecular Weight | 58.7 kDa |
| Observed Molecular Weight | 50-65 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, 1mM DTT, pH 7.4. |
| Reconstitution | Not Applicable |
Background
Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11).