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Recombinant Human Cadherin-11/CDH11 Protein (Fc & His Tag)
SKU: PKSH032137-50
Recombinant Human Cadherin-11/CDH11 Protein (Fc & His Tag)
| SKU # | PKSH032137 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CDH11, Cadherin 11 Type 2 OB-Cadherin (Osteoblast) Isoform CRA_c, Cadherin 11 Type 2 OB-cadherin (Osteoblast) |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Phe23-Thr617 |
| Accession | Q96CZ9 |
| Calculated Molecular Weight | 93.6 kDa |
| Observed Molecular Weight | 110 kDa |
| Tag | C-Fc-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Cadherin-11; also known as OSF-4; Osteoblast cadherin and CDH11; is a type II classical cadherin from the cadherin superfamily; integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells; may thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in brain. Mature cadherin proteins consists of a large N-terminal extracellular domain; a single membrane-spanning domain; and a small; highly conserved C-terminal cytoplasmic domain. It is shown that cadherin-11 is a viable molecular target for therapeutic intervention in Glioblastoma multiforme.