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Recombinant Human Carbonic Anhydrase 8/CA8 Protein (His Tag)(Active)
SKU: PKSH031586-100
Recombinant Human Carbonic Anhydrase 8/CA8 Protein (His Tag)(Active)
| SKU # | PKSH031586 |
| Expression Host | E.coli |
Description
| Synonyms | CA-VIII, CA8, CALS, CAMRQ3, CARP, Carbonic Anhydrase VIII, Carbonic Anhydrase-Related Protein, MGC120502, MGC99509 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Gln 290 |
| Accession | NP_004047.3 |
| Calculated Molecular Weight | 33.8 kDa |
| Observed Molecular Weight | 37 kDa |
| Tag | C-His |
| Bio-activity | Measured by its esterase activity. The specific activity is > 100 pmoles/min/μg. |
Properties
| Purity | > 94 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, 15% glycerol, pH 7.5 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
The carbonic anhydrases (or carbonate dehydratases) are classified as metalloenzyme for its zinc ion prosthetic group and form a family of enzymes that catalyze the rapid interconversion of carbon dioxide and water to bicarbonate and protons, a reversible reaction that takes part in maintaining acid-base balance in blood and other tissues. The carbonic anhydrasekl (CA) family consists of at least 11 enzymatically active members and a few inactive homologous proteins. Carbonic anhydrase protein (CA) VIII, which is a member of the CA gene family, has been shown to have no catalytic CA activity and its biological function is still unknown. Increased expression of CA-RP VIII was observed in 78% of colorectal carcinomas. It suggested that CA-RP VIII plays a role in the process of invasion in colorectal cancer.