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Recombinant Human Carboxypeptidase E/CPE Protein (His Tag)
SKU: PKSH032173-50
Recombinant Human Carboxypeptidase E/CPE Protein (His Tag)
| SKU # | PKSH032173 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Carboxypeptidase E(CPE for short), Carboxypeptidase H, Enkephalin convertase, Prohormone-processing carboxypeptidase |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Arg42-Ser453 |
| Accession | P16870 |
| Calculated Molecular Weight | 47.2 kDa |
| Observed Molecular Weight | 50-60 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Histidine-HCl, 8% Sucrose, 2% Glycine, 20% Glycerol, 0.05% Tween 80, pH 6.5. |
| Reconstitution | Not Applicable |
Background
The active form of CPE cleaves C-terminal amino acid residues of the peptide, and is thus involved in the biosynthesis of peptide hormones and neurotransmitters including insulin, enkephalin, etc. It is thought that membrane-associated CPE acts as a sorting receptor for targeting regulated secretory proteins which are mostly prohormones and neuropeptides in the trans-Golgi network of the pituitary and in secretory granules into the secretory pathway. Defects in this protein are implicated in type II diabetes due to impaired glucose clearance and insulin resistance.