Total Price: $0.00
Contact Information
Recombinant Human Cathepsin B/CTSB Protein (His Tag)
SKU: PKSH032179-50
Recombinant Human Cathepsin B/CTSB Protein (His Tag)
| SKU # | PKSH032179 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | APP Secretase, APPS, CPSB, CTSB, Cathepsin B, Cathepsin B1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Arg18-Ile339 |
| Accession | AAH10240.1 |
| Calculated Molecular Weight | 36.9 kDa |
| Observed Molecular Weight | 34&38-50 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, 8% Sucrose, 0.05% Tween 80, pH7.4. |
| Reconstitution | Not Applicable |
Background
Cathepsin B is an enzymatic protein belonging to the peptidase (or protease) families. The protein encoded by this gene is a lysosomal cysteine protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is a member of the peptidase C1 family. At least five transcript variants encoding the same protein have been found for this gene. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the proteases leaking from lysosomes