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Recombinant Human Cathepsin L/CTSL Protein (His Tag)
SKU: PKSH032182-50
Recombinant Human Cathepsin L/CTSL Protein (His Tag)
| SKU # | PKSH032182 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CTSL, CTSL1, Cathepsin L1, MEP, Major Excreted Protein |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Thr18-Val333 |
| Accession | AAH12612 |
| Calculated Molecular Weight | 36.9 kDa |
| Observed Molecular Weight | 34 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM HAc-NaAc, 150mM NaCl, pH 4.5. |
| Reconstitution | Not Applicable |
Background
Cathepsin L is an enzyme. Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteinases. Cathepsin L plays a major role in antigen processing, tumor invasion and metastasis, bone resorption, and turnover of intracellular and secreted proteins involved in growth regulation. Unlike the precursor forms of other papain family members, the 43 kDa pro-cathepsin L itself is secreted from various cells. Pro-cathepsin L is the major excreted protein of malignantly transformed mouse fibroblasts and is also one of the major acidic cysteine proteases in mammalian cells.