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Recombinant Human Cathepsin Z Protein (His Tag)
SKU: PKSH033443-50
Recombinant Human Cathepsin Z Protein (His Tag)
| SKU # | PKSH033443 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CTSZ, Cathepsin P, Cathepsin X, Cathepsin Z |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gly24-Val303 |
| Accession | Q9UBR2 |
| Calculated Molecular Weight | 32.5 kDa |
| Observed Molecular Weight | 37-40 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 4mM HCl. |
| Reconstitution | Not Applicable |
Background
Cathepsin Z is a lysosomal cysteine proteinase and belongs to the peptidase C1 family. Human Cathepsin Z contains a singnal sequence; a propeptide and a mature chain. It exhibits bothcarboxy-monopeptidase and carboxy-dipeptidase activities. In contrast to cathepsin B; it does not act as an endopeptidase. Cathepsin Z is restricted to the cells of theimmune system; predominantly monocytes; macrophages and dendritic cells. It is expressed ubiquitously in cancer cell lines and primary tumors. Like other members of this family; Cathepsin Z may be involved in tumorigenesis.