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Recombinant Human CD147/Basigin Protein
SKU: PKSH031783-50
Recombinant Human CD147/Basigin Protein
| SKU # | PKSH031783 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | 5F7, BSG, Basigin, CD147, Collagenase Stimulatory Factor, EMMPRIN, Extracellular Matrix Metalloproteinase Inducer, Leukocyte Activation Antigen M6, OK Blood Group Antigen, TCSF, Tumor Cell-Derived Collagenase Stimulatory Factor |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-His 205 |
| Accession | NP_940991.1 |
| Calculated Molecular Weight | 20.7 kDa |
| Observed Molecular Weight | 35-38 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 97 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer); also known as Basigin (BSG); is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis; embryo implantation; neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells; and thereby promotes invasion; metastasis; growth and survival of malignant cells. Furthermore; CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently; CD147 displays increased expression in many cancers; and it has been previously demonstrated to participate in cancer metastasis and progression. Thus; CD147 and its antibody are used as an effective treatment for malignant cancers.