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Recombinant Human CD150/SLAMF1 Protein (His Tag)(Active)
SKU: PKSH031402-100
Recombinant Human CD150/SLAMF1 Protein (His Tag)(Active)
| SKU # | PKSH031402 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD150, CDw150, IPO-3, SLAM, SLAMF1, Signaling Lymphocytic Activation Molecule |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Pro 258 |
| Accession | NP_003028.1 |
| Calculated Molecular Weight | 25.8 kDa |
| Observed Molecular Weight | 45-50 kDa |
| Tag | C-His |
| Bio-activity | Measured by its ability to bind biotinylated recombinant human SH2D1A in a functional ELISA. |
Properties
| Purity | > 97 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
CD150/signaling lymphocytic activation molecule (SLAM) is a cell surface sialylated phosphoglycoprotein and belongs to the CD2 subset of the Ig superfamily of type I transmembrane glycoproteins. The CD150 receptor is expressed on thymocytes, activated and memory T cells, B cells, platelets, natural killer T cells, and mature dendritic cells, and is also detected on tumor cells of Hodgkin's lymphoma (HL) and diffuse large B-cell lymphoma with an activated B cell phenotype. Additionally, it is the immune cell receptor for measles virus (MV). As a self-ligand, CD150 performs diverse immunologic functions including T/B-cell costimulation, induction of IFN-&gamma in Th1 T-cell clones, redirection of Th2 clones to a Th1 or Th0 phenotype, and inhibition of apoptosis in B cells. Furthermore, CD150 was shown to be the second receptor for measles virus in addition to CD46, and the distribution of SLAM on various cell lines is consistent with their susceptibility to clinical isolates of measles virus.