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Recombinant Human CD155/PVR/NECL5 Protein (mFc Tag)– MSE Supplies LLC

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Recombinant Human CD155/PVR/NECL5 Protein (mFc Tag)

SKU: PKSH033561-50

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Recombinant Human CD155/PVR/NECL5 Protein (mFc Tag)

 

SKU # PKSH033561
Expression Host HEK293 Cells

 

 

Description

Synonyms CD155, NECL-5, Nectin-Like Protein 5, PVR, PVS, Poliovirus Receptor
Species Human
Expression Host HEK293 Cells
Sequence Trp21-Asn343
Accession P15151
Calculated Molecular Weight 61.7 kDa
Observed Molecular Weight 80-110 kDa
Tag C-mFc
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains; a transmembrane segment; and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (α; β; γ; and δ) with identical extracellular domains.