Recombinant Human CD155/PVR/NECL5 Protein (mFc Tag)
SKU: PKSH033561-50
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Recombinant Human CD155/PVR/NECL5 Protein (mFc Tag)
SKU # | PKSH033561 |
Expression Host | HEK293 Cells |
Description
Synonyms | CD155, NECL-5, Nectin-Like Protein 5, PVR, PVS, Poliovirus Receptor |
Species | Human |
Expression Host | HEK293 Cells |
Sequence | Trp21-Asn343 |
Accession | P15151 |
Calculated Molecular Weight | 61.7 kDa |
Observed Molecular Weight | 80-110 kDa |
Tag | C-mFc |
Bio-activity | Not validated for activity |
Properties
Purity | > 95 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
Reconstitution | Please refer to the printed manual for detailed information. |
Background
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains; a transmembrane segment; and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (α; β; γ; and δ) with identical extracellular domains.