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Recombinant Human CD155/PVR Protein (His Tag)(Active)
SKU: PKSH031868-100
Recombinant Human CD155/PVR Protein (His Tag)(Active)
| SKU # | PKSH031868 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD155, HVED, NECL5, Necl-5, PVS, TAGE4 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Asn 343 |
| Accession | NP_006496.3 |
| Calculated Molecular Weight | 36.5 kDa |
| Observed Molecular Weight | 60-65 kDa |
| Tag | C-His |
| Bio-activity | Immobilized human CD155 at 2 μg/ml (100 μl/well) can bind human DNAM1 with a linear ranger of 1. 28-32 ng/ml. |
Properties
| Purity | > 97 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.5 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
CD155; commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5); is a type I transmembrane single-span glycoprotein; and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhension; migration and NK-cell killing; and thus efficiently prime cell-mediated tumor-specific immunity.