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Recombinant Human CD208/LAMP3/DC-LAMP Protein (His Tag)– MSE Supplies LLC

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Recombinant Human CD208/LAMP3/DC-LAMP Protein (His Tag)

SKU: PKSH031547-100

  • £62200
  • Save £6900



Recombinant Human CD208/LAMP3/DC-LAMP Protein (His Tag)

 

SKU # PKSH031547
Expression Host HEK293 Cells

 

 

Description

Synonyms CD208, DC LAMP, DC-LAMP, DCLAMP, LAMP, LAMP-3, TSC403
Species Human
Expression Host HEK293 Cells
Sequence Lys 28-Thr 381
Accession NP_055213.2
Calculated Molecular Weight 39.0 kDa
Observed Molecular Weight 70-90 kDa
Tag C-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces.