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Recombinant Human CD300a/LMIR1 Protein (His Tag)
SKU: PKSH032699-50
Recombinant Human CD300a/LMIR1 Protein (His Tag)
| SKU # | PKSH032699 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD300 Antigen-Like Family Member A, CD300A, CD300a, CLM-8, CMRF-35-H9, CMRF35-H, CMRF35-H9, CMRF35-Like Molecule 8, CMRF35H, IGSF12, IRC1/IRC2, IRp60, IgSF12, Immunoglobulin Superfamily Member 12, Inhibitory Receptor Protein 60, NK Inhibitory Receptor |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu18-Gln178 |
| Accession | Q9UGN4 |
| Calculated Molecular Weight | 18.5 kDa |
| Observed Molecular Weight | 23-37 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
CD300A is a single-pass type I membrane protein that belongs to the CD300 family. CD300A consists of a 163 amino acid (aa) extracellular domain (ECD) with one Ig-like V- type domain; a 21 amino acid transmembrane segment; and a 98 amino acid cytoplasmic domain with tyrosine residues. CD300A is expressed not only by natural killer (NK) cells but also by T-cell subsets; B-cells; dendritic cells; mast cells; granulocytes and monocytes. CD300A is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells; and to the down-regulation of mast cell degranulation.