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Recombinant Human CHI3L1/YKL40 Protein (His Tag)
SKU: PKSH033717-50
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Recombinant Human CHI3L1/YKL40 Protein (His Tag)
| SKU # | PKSH033717 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | 39 kDa Synovial Protein, ASRT7, CGP-39, CHI3L1, Cartilage Glycoprotein 39, Chitinase-3-Like protein 1, DKFZp686N19119, FLJ38139, GP-39, GP39, HC-gp39, HCGP-3P, YKL-40, YKL40, YYL-40, hCGP-39 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Tyr22-Thr383 |
| Accession | P36222 |
| Calculated Molecular Weight | 41.5 kDa |
| Observed Molecular Weight | 46 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, 2mM EDTA, pH8.5. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Chitinase-3-Like Protein 1 (CHI3L1) belongs to the glycosyl hydrolase 18 family. CHI3L1 is expressed in activated macrophages, articular chondrocytes, synovial cells as well as in liver. It lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. CHI3L1 is thought to play a role in defense against pathogens, or in tissue remodeling, and in the capacity of cells to respond to and cope with changes in their environment. In addition, CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) which assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.