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Recombinant Human CLEC4E/Mincel Protein (His Tag)
SKU: PKSH032258-50
Recombinant Human CLEC4E/Mincel Protein (His Tag)
| SKU # | PKSH032258 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | C-Type Lectin Domain Family 4 Member E, C-Type Lectin Superfamily Member 9, CLEC4E, CLECSF9, MINCLE, Macrophage-Inducible C-Type Lectin |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Arg41-Leu219 |
| Accession | Q9ULY5 |
| Calculated Molecular Weight | 21.7 kDa |
| Observed Molecular Weight | 26 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
C-Type Lectin Domain Family 4 Member E (CLEC4E) is a 219 amino acid single-pass type II membrane protein that contains one C-type Lectin domain. It is expressed in monocytes, CLEC4E functions as a downstream target of C/EBP β and is thought to play a role in the inflammatory response, possibly via transcriptional control of C/EBP β. CLEC4E may play a role in the response to inflammatory stimuli in peritoneal macrophages and may be involved in immune surveillance processes under transcriptional control of CEBPB. Human CLEC4E shares 67% sequence identity with its mouse counterpart, suggesting a similar function between species. CLEC-4E exists as multiple alternatively spliced isoforms that are encoded by a gene which maps to a natural killer gene complex region on human chromosome 12.