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Recombinant Human CMPK1 Protein (His Tag)
SKU: PKSH030319-50
Recombinant Human CMPK1 Protein (His Tag)
| SKU # | PKSH030319 |
| Expression Host | Baculovirus-Insect Cells |
Description
| Synonyms | CK, CMK, CMPK, UMK, UMP-CMPK, UMPK |
| Species | Human |
| Expression Host | Baculovirus-Insect Cells |
| Sequence | Met 1-Gly 196 |
| Accession | P30085 |
| Calculated Molecular Weight | 24.5 kDa |
| Observed Molecular Weight | 27 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as sterile solution of 20mM Tris, 500mM Nacl, pH 7.4, 10% glycerol |
| Reconstitution | Not Applicable |
Background
CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. CMPK1 also has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. In the meanwhile, CMPK1 functions in cellular nucleic acid biosynthesis.