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Recombinant Human CNDP1 Protein (His Tag)
SKU: PKSH033451-50
Recombinant Human CNDP1 Protein (His Tag)
| SKU # | PKSH033451 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | Beta-Ala-His Dipeptidase, CN1, CNDP Dipeptidase 1, CNDP1, CPGL2, Carnosine Dipeptidase 1, Glutamate Carboxypeptidase-Like Protein 2, HsT2308, Serum Carnosinase |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Pro28-His507 |
| Accession | AAI13513.1 |
| Calculated Molecular Weight | 54.9 kDa |
| Observed Molecular Weight | 60-90 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 7.5. |
| Reconstitution | Not Applicable |
Background
Carnosine Dipeptidase 1 (CNDP1) belongs to the M20 metalloprotease family. CNDP1 is specifically expressed in the brain; serum and adult nervous central system. It is identified as human carnosinase. CNDP1 contains trinucleotide (CTG) repeat length polymorphism in the coding region and is inhibited by the metal chelator 1;10-o-phenantrolin. In addition; CNDP1 can hydrolyse the beta-Ala|-His dipeptide (carnosine); anserine; Xaa-|-His dipeptides and other dipeptides including homocarnosine. CNDP1 deficiency has been associated with homocarnosinosis disease.