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Recombinant Human CTGF/CCN2 Protein (Fc Tag)
SKU: PKSH032276-50
Recombinant Human CTGF/CCN2 Protein (Fc Tag)
| SKU # | PKSH032276 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CCN family member 2, CTGF, Connective tissue growth factor, Hypertrophic chondrocyte-specific protein 24, IGFBP8, Insulin-like growth factor-binding protein 8 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln27-Ala349 |
| Accession | Q5M8T4 |
| Calculated Molecular Weight | 62.6 kDa |
| Observed Molecular Weight | 67-81 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family; which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF causes a variety of cellular responses including reduced cell adhesion and enhanced cell migration and proliferation. CTGF has also been shown to be essential for epithelial to mesenchymal transition (EMT); a process whereby normal functioning cells morph into ones that produce mainly scar tissue (of which collagen in the major protein component).