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Recombinant Human Cyr61/CCN1 Protein (Fc Tag)
SKU: PKSH032318-50
Recombinant Human Cyr61/CCN1 Protein (Fc Tag)
| SKU # | PKSH032318 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CCN family member 1, CCN1, CYR61, Cysteine-rich angiogenic inducer 61, GIG1, IGFBP10, Insulin-like growth factor-binding protein 10, Protein CYR61 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Thr 25-Asp381 |
| Accession | O00622 |
| Calculated Molecular Weight | 66.5 kDa |
| Observed Molecular Weight | 71 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Protein CYR61, also known as CCN family member 1, Cysteine-rich angiogenic inducer 61,Insulin-like growth factor-binding protein 10 , GIG1, CYR61, CCN1 and IGFBP10, belongs to the CCN family, CYR61 is a secreted protein and contains one CTCK (C-terminal cystine knot-like) domain,one IGFBP N-terminal domain,one TSP type-1 domain and one VWFC domain. CYR61 promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. CYR61 plays important roles in inflammation and tissue repair. CYR61 is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers.