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Recombinant Human Cystatin C/CST3 Protein (E.coli)
SKU: PKSH032322-50
Recombinant Human Cystatin C/CST3 Protein (E.coli)
| SKU # | PKSH032322 |
| Expression Host | E.coli |
Description
| Synonyms | ARMD11, Cystatin-3, Gamma-trace, Neuroendocrine basic polypeptide, Post-gamma-globulin |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Gly26-Ala146 |
| Accession | P01034 |
| Calculated Molecular Weight | 13.4 kDa |
| Observed Molecular Weight | 14 kDa |
| Tag | None |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM HEPES, 150mM NaCl, 1mM EDTA, 5% sucrose, pH7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Cystatin C is a member of family 2 of the cystatin superfamily. It is ubiquitous in human tissues and body fluids and mainly used as a biomarker of kidney function. Cystatin C inhibits many cysteine proteases such as papain and Cathepsins B; H; K; L and S. As an inhibitor of cysteine proteinases; Cystatin C is thought to serve an important physiological role as a local regulator of this enzyme activity. Recently; it has been studied for its role in predicting new-onset or deteriorating cardiovascular disease. It also seems to play a role in brain disorders involving amyloid (a specific type of protein deposition); such as Alzheimer's disease.