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Recombinant Human DFFA Protein (His Tag)
SKU: PKSH032359-50
Recombinant Human DFFA Protein (His Tag)
| SKU # | PKSH032359 |
| Expression Host | E.coli |
Description
| Synonyms | DFF-45, DFF1, DFF45, DFFA, DNA Fragmentation Factor 45 kDa Subunit, DNA Fragmentation Factor Subunit Alpha, H13, ICAD, Inhibitor of CAD |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Thr331 |
| Accession | AAH07721.1 |
| Calculated Molecular Weight | 38.7 kDa |
| Observed Molecular Weight | 40-50 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.4. |
| Reconstitution | Not Applicable |
Background
DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.