Total Price: $0.00
Contact Information
Recombinant Human EDNRB/Endothelin B Receptor Protein (Fc Tag)
SKU: PKSH030546-100
Recombinant Human EDNRB/Endothelin B Receptor Protein (Fc Tag)
| SKU # | PKSH030546 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | ABCDS, ET-B, ET-BR, ETB, ETBR, ETRB, HSCR, HSCR2, WS4A |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Met 1-Lys101 |
| Accession | NP_000106.1 |
| Calculated Molecular Weight | 34.4 kDa |
| Observed Molecular Weight | 47.5&43.7 kDa |
| Tag | C-mFc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
The hypermethylation of EDNRB gene was remarkably related to infiltration and metastasis of gastric cancer and may attribute to the tumor progression. EDNRB is a new candidate tumor suppressor gene which is often down-regulated or even silenced by promoter hypermethylation in various human cancers. Low EDNRB expression played a role in the progression of ACC tumors. The autosomal recessive mutation in EDNRB may underlie a part of WS1 with the current diagnostic criteria, and supported that Hirschsprung's disease is a multifactorial genetic disease which requires additional factors.