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Recombinant Human EGR1 Protein (His Tag)– MSE Supplies LLC

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Recombinant Human EGR1 Protein (His Tag)

SKU: PKSH032369-50

  • £38100
  • Save £4300



Recombinant Human EGR1 Protein (His Tag) 

 

SKU # PKSH032369
Expression Host E.coli

 

 

Description

Synonyms EGR-1, Early growth response protein 1, NGFI-A, Zif268, nerve growth factor-induced protein A, zinc finger protein 225
Species Human
Expression Host E.coli
Sequence Gln282-Ser433
Accession P18146
Calculated Molecular Weight 19.9 kDa
Observed Molecular Weight 19 kDa
Tag N-His
Bio-activity Not validated for activity
  

 

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

EGR-1 belongs to the EGR family of C2H2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. EGR-1 recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site).The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a tumor suppressor gene. EGR-1 has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies suggest it has a role in neuronal plasticity. EGR-1 has also been found to regulate the expression of synaptobrevin II (a protein important for synaptic exocytosis).