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Recombinant Human Ephrin-A1/EFNA1 Protein (Fc Tag)(Active)– MSE Supplies LLC

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Recombinant Human Ephrin-A1/EFNA1 Protein (Fc Tag)(Active)

SKU: PKSH032389-50

  • £21700
  • Save £2400



Recombinant Human Ephrin-A1/EFNA1 Protein (Fc Tag)(Active)

 

SKU # PKSH032389
Expression Host HEK293 Cells

 

 

Description

Synonyms EFNA1, EPH-Related Receptor Tyrosine Kinase Ligand 1, EPLG1, Ephrin-A1, Immediate Early Response Protein B61, LERK-1, LERK1, TNF Alpha-Induced Protein 4, TNFAIP4, Tumor Necrosis Factor Alpha-Induced Protein 4
Species Human
Expression Host HEK293 Cells
Sequence Asp19-Ser182
Accession AAH32698.1
Calculated Molecular Weight 46.5 kDa
Observed Molecular Weight 55-60 kDa
Tag C-Fc
Bio-activity Not validated for activity
  

 

Properties

Purity > 85 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.



Background

Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the relocalization of EPHA2 away from sites of cell-cell contact during transformation. Ephrin-A1 plays an important role in angiogenesis and tumor neovascularization.