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Recombinant Human Erythropoietin R/EPOR Protein (Fc Tag)
SKU: PKSH033686-50
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Recombinant Human Erythropoietin R/EPOR Protein (Fc Tag)
| SKU # | PKSH033686 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | EPO-R, EpoR, Erythropoietin R, MGC138358, Platelet Receptor EPO-R, erythropoietin receptor |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala25-Pro250 |
| Accession | P19235 |
| Calculated Molecular Weight | 52 kDa |
| Observed Molecular Weight | 55-75 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 6% Trehalose, 4% Mannitol, 0.05% Tween 80, pH 7.5. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Erythropoietin (Epo); a glycoprotein produced primarily by the kidney; is the principal factor that regulates erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells. The biological effects of Epo are mediated by the erythropoietin receptor (Epo R). The presence of a soluble form of the Epo R has also been detected on human sera. Recombinant soluble Epo R binds Epo with high affinity and is a potent Epo antagonist.