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Recombinant Human FABP6/I-BABP Protein (His Tag)
SKU: PKSH033681-50
Recombinant Human FABP6/I-BABP Protein (His Tag)
| SKU # | PKSH033681 |
| Expression Host | E.coli |
Description
| Synonyms | FABP6, Fatty Acid-Binding Protein 6, GT, Gastrotropin, I-15P, I-BABP, ILBP, ILLBP, Ileal Lipid-Binding Protein, Intestinal 15 kDa Protein, Intestinal Bile Acid-Binding Protein |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met1-Ala128 |
| Accession | AAH22489.1 |
| Calculated Molecular Weight | 16.6 kDa |
| Observed Molecular Weight | 15 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 0.5mM DTT, 50% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Fatty Acid-Binding Protein 6 (FABP6) is cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands which belongs to the calycin superfamily. FABP6 expression is restricted in the small intestine to the ileum where it is involved in the enterohepatic circulation of bile acids. FABP6 forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. FABP6 plays a role in fatty acid uptake, transport, and metabolism. FABP6 stimulates gastric acid and pepsinogen secretion. It seems to be able to bind to bile salts and bilirubins.