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Recombinant Human FBPase 1/FBP1 Protein (Human Cells, His Tag)
SKU: PKSH033277-50
Recombinant Human FBPase 1/FBP1 Protein (Human Cells, His Tag)
| SKU # | PKSH033277 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | 6-bisphosphatase 1, 6-bisphosphate 1-phosphohydrolase 1, D-fructose-1, FBP, FBPase 1, Fructose-1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala2-Gln338 |
| Accession | P09467 |
| Calculated Molecular Weight | 37.8 kDa |
| Observed Molecular Weight | 35-38 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 1mMEDTA, 10% Glycerol, pH 8.0. |
| Reconstitution | Not Applicable |
Background
Fructose-1;6-bisphosphatase 1(FBP1) is a homotetramer protein and belongs to the FBPase class 1 family. It involves in carbohydrate biosynthesis; gluconeogenesis pathway. FBP1 is a gluconeogenesis regulatory protein which catalyzes the hydrolysis of fructose 1;6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBP1 deficiency is associated with hypoglycemia and metabolic acidosis. FBP1 regulates mouse endogenous glucose production. FBP1 coupled with phosphofructokinase (PFK) takes part in the metabolism of pancreatic islet cells.