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Recombinant Human FCRL1 Protein (His Tag)
SKU: PKSH033364-50
Recombinant Human FCRL1 Protein (His Tag)
| SKU # | PKSH033364 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | CD307a, FCRH1, FCRL1, Fc Receptor Homolog 1, Fc Receptor-Like Protein 1, FcR-Like Protein 1, FcRH1, FcRL1, IFGP Family Protein 1, IFGP1, IRTA5, Immune Receptor Translocation-Associated Protein 5, hIFGP1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala17-Asn303 |
| Accession | Q96LA6 |
| Calculated Molecular Weight | 32.2 kDa |
| Observed Molecular Weight | 39-50 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 1mM EDTA, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Fc Receptor-Like Protein 1 (FCRL1) is a single-pass type I membrane protein that may function as an activating coreceptor in B cells. FCRL1 is primarily expressed in secondary lymphoid tissues by mature subsets of B cells. It can be detected in the spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. It is specifically expressed by mature B lineage cells with higher expression at the protein level in naive B cells compared to memory B cells. FCRL1 contains three extracellular C2-like immunoglobulin domains, a transmembrane domain, and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs and may play a role in the regulation of cancer cell growth.