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Recombinant Human FGFR5/FGFRL1 Protein (His Tag)(Active)
SKU: PKSH032427-50
Recombinant Human FGFR5/FGFRL1 Protein (His Tag)(Active)
| SKU # | PKSH032427 |
| Expression Host | HEK293 Cells |
Description
| Synonyms | FGF Homologous Factor Receptor, FGF Receptor-Like Protein 1, FGFR-5, FGFR-Like Protein, FGFR5, FGFRL1, FHFR, Fibroblast Growth Factor Receptor 5, Fibroblast Growth Factor Receptor-Like 1 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Ala25-Pro378 |
| Accession | Q8N441 |
| Calculated Molecular Weight | 39.9 kDa |
| Observed Molecular Weight | 65 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) is a single-pass type I membrane protein that belongs to the FGF receptor family. The mature human FGFRL1 consists of a 354 amino acid extracellular domain (ECD) with 3 Ig-like C2-type domains, a 21 amino acid transmembrane segment, and a 134 amino acid cytoplasmic domain. FGFR1 expressed in various tissues, preferentially in cartilaginous tissues and pancreas. It highly expressed in the liver, kidney, heart, brain and skeletal muscle, weakly expressed in the lung, small intestine and spleen. FGFRL1 has a negative effect on cell proliferation.