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Recombinant Human FKBP3/FKBP25 Protein (GST Tag)
SKU: PKSH030809-100
Recombinant Human FKBP3/FKBP25 Protein (GST Tag)
| SKU # | PKSH030809 |
| Expression Host | E.coli |
Description
| Synonyms | 25 kDa FK506-binding protein, 25 kDa FKBP, FK506-binding protein 3, FKBP-25, FKBP-3, FKBP25, Immunophilin FKBP25, PPIase FKBP3, Peptidyl-prolyl cis-trans isomerase FKBP3, Rapamycin-selective 25 kDa immunophilin, Rotamase |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Ala 2-Asp 224 |
| Accession | Q00688 |
| Calculated Molecular Weight | 52.0 kDa |
| Observed Molecular Weight | 48 kDa |
| Tag | N-GST |
| Bio-activity | Not validated for activity |
Properties
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from sterile 50mM tris, 0.15M NaCl, 0.5mM GSH, pH 8.0 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
Background
BLBP; also known as FABP7; is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small; highly conserved; cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP7 binds DHA with the highest affinity among all of the FABPs. FABPs may play roles in fatty acid uptake; transport; and metabolism. BLBP is expressed; during development; in radial glia by the activation of notch receptors. It was shown that reelin induces FABP7 expression in neural progenitor cells via notch-1 activation. BLBP variation is linked to weak prepulse inhibition(PPI) in mice and deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.