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Recombinant Human Frizzled-7 protein (His tag)– MSE Supplies LLC

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Recombinant Human Frizzled-7 protein (His tag)

Recombinant Human Frizzled-7 protein (His tag)

SKU: PDEH100402-100

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Recombinant Human Frizzled-7 protein (His tag)

 

SKU # PDEH100402
Expression Host E. coli

 

Description    

Synonyms Frizzled-7;FZD7;
Species Human
Expression_host E.coli
Sequence Gly31-Arg250
Accession O75084
Mol_Mass 24.1 kDa
AP_Mol_Mass 32 kDa
Tag C-His
Bio_Activity Not validated for activity
  


Propertie

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level Please contact us for more information.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis


Background

Frizzled-7 is a member of the Frizzled family of unconventional G-protein-coupled glycoprotein receptors for the Wnt signaling pathway . The Wnt genes encode a large family of glycoproteins that are essential in development and tissue maintenance . Like other Frizzled family members, Frizzled-7 contains a divergent N-terminal signal peptide (amino acid (aa) 1 - 32), a highly conserved extracellular cysteine-rich domain (CRD, aa 44 - 169), a variable-length linker region (aa 170 ? 256), a seven-pass transmembrane region (aa 257 - 549), and a variable-length C-terminal cytoplasmic domain (aa 550 - 574) (1 - 3). The CRD, which comprises the binding site for Wnts and other ligands such as Syndecan 4 and fibronectin, spans about 130 amino acid residues and contains ten invariant cysteine residue.